Biopolymer‐based Carriers for DNA Vaccine Design

Over the last 30 years, genetically engineered DNA has been tested as novel vaccination strategy against various diseases, including human immunodeficiency virus (HIV), hepatitis B, several parasites, and cancers. However, clinical breakthrough of technique is confined by low transfection efficacy immunogenicity employed vaccines. Therefore, carrier materials were designed to prevent rapid degradation systemic clearance in body. In this context, biopolymers are a particularly promising vaccine platform due their beneficial biochemical physical characteristics, biocompatibility, stability, toxicity. This article reviews applications, fabrication, modification medium for genetic